Activation of the sigma-1 receptor exerts cardioprotection in a rodent model of chronic heart failure by stimulation of angiogenesis

• Main Authors: Xin Zhao (Author), Xin Liu (Author), Xiuhuan Chen (Author), Xueyu Han (Author), Yazhou Sun (Author), Yuhong Fo (Author), Xiukun Wang (Author), Chuan Qu (Author), Bo Yang (Author)
• Format: Book
• Published: BMC, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Angiogenesis plays a critical role on post-infarction heart failure (PIHF), the presence of which facilitates additional blood supply to maintain the survival of residual cardiomyocytes. The sigma-1 receptor (S1R) has been substantiated to stimulate angiogenesis, with the effect...