Clinical Phenotypes Associated to Engrailed 2 Gene Alterations in a Series of Neuropediatric Patients

• Main Authors: Francisco Carratala-Marco (Author), Patricia Andreo-Lillo (Author), Marta Martinez-Morga (Author), Teresa Escamez-Martínez (Author), Arancha Botella-López (Author), Carlos Bueno (Author), Salvador Martinez (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The engrailed homeobox protein (EN) plays an important role in the regionalization of the neural tube. EN distribution regulates the cerebellum and midbrain morphogenesis, as well as retinotectal synaptogenesis. In humans, the EN1 and EN2 genes code for the EN family of transcription factors. Geneti...