Short-course eflornithine in Gambian trypanosomiasis: a multicentre randomized controlled trial

• Main Authors: Jacques Pépin (Author), Nzambi Khonde (Author), Faustine Maiso (Author), Félix Doua (Author), Shabbar Jaffar (Author), Stéphane Ngampo (Author), Bokelo Mpia (Author), Dawson Mbulamberi (Author), Felix Kuzoe (Author)
• Format: Book
• Published: The World Health Organization, 2000-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

OBJECTIVE: A randomized controlled trial was conducted to determine whether 7 days of intravenous eflornithine (100 mg/kg every 6 h) was as effective as the standard 14-day regimen in the treatment of late-stage Trypanosoma brucei gambiense trypanosomiasis. METHODS: A total of 321 patients (274 new...