Effect of quercetin on the pharmacokinetics of selexipag and its active metabolite in beagles

• Hauptverfasser: Shun-bin Luo (Verfasst von), Er-min Gu (Verfasst von), Yu-ao Chen (Verfasst von), Shi-chen Zhou (Verfasst von), Chen Fan (Verfasst von), Ren-ai Xu (Verfasst von)
• Format: Buch
• Veröffentlicht: Taylor & Francis Group, 2022-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Context As an inhibitor cytochrome P450 family 2 subfamily C polypeptide 8 (CYP2C8), quercetin is a naturally occurring flavonoid with its glycosides consumed at least 100 mg per day in food. However, it is still unknown whether quercetin and selexipag interact. Objective The study investigated the...