Effect of quercetin on the pharmacokinetics of selexipag and its active metabolite in beagles

• Ngā kaituhi matua: Shun-bin Luo (Author), Er-min Gu (Author), Yu-ao Chen (Author), Shi-chen Zhou (Author), Chen Fan (Author), Ren-ai Xu (Author)
• Hōputu: Pukapuka
• I whakaputaina: Taylor & Francis Group, 2022-01-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Context As an inhibitor cytochrome P450 family 2 subfamily C polypeptide 8 (CYP2C8), quercetin is a naturally occurring flavonoid with its glycosides consumed at least 100 mg per day in food. However, it is still unknown whether quercetin and selexipag interact. Objective The study investigated the...