Ablation of intact hypothalamic and/or hindbrain TrkB signaling leads to perturbations in energy balance

• Main Authors: Ceren Ozek (Author), Derek J. Zimmer (Author), Bart C. De Jonghe (Author), Robert G. Kalb (Author), Kendra K. Bence (Author)
• 格式: 图书
• 出版: Elsevier, 2015-11-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Objective: Brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin receptor kinase B (TrkB), play a paramount role in the central regulation of energy balance. Despite the substantial body of genetic evidence implicating BDNF- or TrkB-deficiency in human obesity, the critical brain re...