Ruthenium complexes show potent inhibition of AKR1C1, AKR1C2, and AKR1C3 enzymes and anti-proliferative action against chemoresistant ovarian cancer cell line

Ruthenium complexes show potent inhibition of AKR1C1, AKR1C2, and AKR1C3 enzymes and anti-proliferative action against chemoresistant ovarian cancer cell line

In this study, we present the synthesis, kinetic studies of inhibitory activity toward aldo-keto reductase 1C (AKR1C) enzymes, and anticancer potential toward chemoresistant ovarian cancer of 10 organoruthenium compounds bearing diketonate (1-6) and hydroxyquinolinate (7-10) chelating ligands with t...

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Main Authors: Jakob Kljun (Author), Renata Pavlič (Author), Eva Hafner (Author), Tanja Lipec (Author), Sara Moreno-Da Silva (Author), Primož Tič (Author), Iztok Turel (Author), Tomaž Büdefeld (Author), Jure Stojan (Author), Tea Lanišnik Rižner (Author)
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Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
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