In silico prediction, molecular modeling, and dynamics studies on the targeted next-generation sequencing identified genes underlying congenital heart disease in Down syndrome patients

• Main Authors: Fiona Hannah Carlus (Author), L Balasubramaniam Sujatha (Author), Anbazhagan Ganesh Kumar (Author), Lakshmanan Loganathan (Author), Karthikeyan Muthusamy (Author), Silas Justin Carlus (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background : Individuals with Down syndrome (DS) have a 40%-60% chance of being born with congenital heart disease (CHD). This indicates that CHD in individuals with DS is not solely caused by trisomy 21, and there may be other genetic factors contributing to the development of CHD in these children...