Dose escalation PET imaging for safety and effective therapy dose optimization of a bispecific antibody

• Main Authors: Yan Wang (Author), Donghui Pan (Author), Chenrong Huang (Author), Bingliang Chen (Author), Mingzhu Li (Author), Shuaixiang Zhou (Author), Lizhen Wang (Author), Min Wu (Author), Xinyu Wang (Author), Yicong Bian (Author), Junjie Yan (Author), Junjian Liu (Author), Min Yang (Author), Liyan Miao (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Selecting the dose for efficacy and first-in-human studies of bispecific antibodies (BsAbs) is a challenging process. Herein, positron emission tomography (PET) imaging with 89Zr-labeled IBI322, an anti-CD47/PD-L1 BsAb, was used to optimize the safety and effective therapy dose. By labeling with 89Z...