Chitosan-Based Microparticles Enhance Ellagic Acid's Colon Targeting and Proapoptotic Activity

• Main Authors: Nabil A. Alhakamy (Author), Osama A. A. Ahmed (Author), Mallesh Kurakula (Author), Giuseppe Caruso (Author), Filippo Caraci (Author), Hani Z. Asfour (Author), Anas Alfarsi (Author), Basma G. Eid (Author), Amir I. Mohamed (Author), Nabil K. Alruwaili (Author), Wesam H. Abdulaal (Author), Usama A. Fahmy (Author), Hani A. Alhadrami (Author), Basmah M. Eldakhakhny (Author), Ashraf B. Abdel-Naim (Author)
• Format: Book
• Published: MDPI AG, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study aimed at improving the targeting and cytotoxic effect of ellagic acid (EA) on colon cancer cells. EA was encapsulated in chitosan (CHIT) polymers then coated by eudragit S100 (ES100) microparticles. The release of EA double-coated microparticles (MPs) was tested at simulative pH values. M...