Cytochrome P450 Expression and Chemical Metabolic Activity before Full Liver Development in Zebrafish

• Main Authors: Tasuku Nawaji (Author), Natsumi Yamashita (Author), Haruka Umeda (Author), Shuangyi Zhang (Author), Naohiro Mizoguchi (Author), Masanori Seki (Author), Takio Kitazawa (Author), Hiroki Teraoka (Author)
• Format: Book
• Published: MDPI AG, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Zebrafish are used widely in biomedical, toxicological, and developmental research, but information on their xenobiotic metabolism is limited. Here, we characterized the expression of 14 xenobiotic cytochrome P450 (CYP) subtypes in whole embryos and larvae of zebrafish (4 to 144 h post-fertilization...