Pantoprazole (PPZ) Inhibits RANKL-Induced Osteoclast Formation and Function In Vitro and Prevents Lipopolysaccharide- (LPS-) Induced Inflammatory Calvarial Bone Loss In Vivo

• Main Authors: Yu-Xi Li (Author), Fu-Chao Chen (Author), Ting Liu (Author), Zhao-Peng Cai (Author), Keng Chen (Author), Guo-Xue Tang (Author), Jun-Shen Huang (Author), Xiang-Ge Liu (Author), Jia-Jun Huang (Author), Peng Wang (Author), Yu-Wei Liang (Author), Lin Huang (Author)
• Format: Book
• Published: Hindawi Limited, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bone remodeling is a process delicately balanced between osteoclastic bone resorption and osteoblastic bone formation. Osteoclasts (OCs) are multinucleated giant cells formed through the fusion of monocytic precursors of the hematopoietic stem cells lineage. OCs are the exclusive cells responsible f...