Overexpressed SIRT6 ameliorates doxorubicin-induced cardiotoxicity and potentiates the therapeutic efficacy through metabolic remodeling

• Main Authors: Kezheng Peng (Author), Chenye Zeng (Author), Yuqi Gao (Author), Binliang Liu (Author), Liyuan Li (Author), Kang Xu (Author), Yuemiao Yin (Author), Ying Qiu (Author), Mingkui Zhang (Author), Fei Ma (Author), Zhao Wang (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Since the utilization of anthracyclines in cancer therapy, severe cardiotoxicity has become a major obstacle. The major challenge in treating cancer patients with anthracyclines is minimizing cardiotoxicity without compromising antitumor efficacy. Herein, histone deacetylase SIRT6 expression was red...