Rational design of structure‐based vaccines targeting misfolded alpha‐synuclein conformers of Parkinson's disease and related disorders

• Main Authors: Jose Miguel Flores‐Fernandez (Author), Verena Pesch (Author), Aishwarya Sriraman (Author), Enrique Chimal‐Juarez (Author), Sara Amidian (Author), Xiongyao Wang (Author), Caleb Duckering (Author), Andrew Fang (Author), Sara Reithofer (Author), Liang Ma (Author), Leonardo M. Cortez (Author), Valerie L. Sim (Author), Gültekin Tamgüney (Author), Holger Wille (Author)
• Format: Book
• Published: Wiley, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Synucleinopathies, including Parkinson's disease (PD), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB), are neurodegenerative disorders caused by the accumulation of misfolded alpha‐synuclein protein. Developing effective vaccines against synucleinopathies is challen...