Unexpected excessive apixaban exposure: case report of a patient with polymorphisms of multiple apixaban elimination pathways

• Main Authors: Andrea Huppertz (Author), Caspar Grond-Ginsbach (Author), Chris Dumschat (Author), Kathrin I. Foerster (Author), Jürgen Burhenne (Author), Johanna Weiss (Author), David Czock (Author), Jan C. Purrucker (Author), Timolaos Rizos (Author), Walter E. Haefeli (Author)
• Format: Book
• Published: BMC, 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Apixaban effectively lowers the risk of ischemic stroke and systemic embolism in patients with non-valvular atrial fibrillation. Systemic exposure to a given apixaban dose depends on multiple clearance pathways. Though routine quantification of direct oral anticoagulants (DOACs)...