Reduced mitochondrial complex II activity enhances cell death via intracellular reactive oxygen species in STHdhQ111 striatal neurons with mutant huntingtin

• Autori principali: Noria Okada (Autore), Tomohiro Yako (Autore), Shinsuke Nakamura (Autore), Masamitsu Shimazawa (Autore), Hideaki Hara (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2021-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by CAG repeat expansion in the huntingtin (HTT) gene. Here, we examined the effects of antioxidants on 3-nitropropionic acid (3-NP; a mitochondrial complex II inhibitor)-induced mitochondrial dysfunction and cell death...