Idiopathic splenomegaly in childhood and the spectrum of RAS-associated lymphoproliferative disease: a case report

• Main Authors: Geraldine Blanchard-Rohner (Author), Robert J. Ragotte (Author), Anne K. Junker (Author), Mehul Sharma (Author), Kate L. Del Bel (Author), Henry Y. Lu (Author), Stephanie Erdle (Author), Alanna Chomyn (Author), Harinder Gill (Author), Lori B. Tucker (Author), Richard A. Schreiber (Author), Jacob Rozmus (Author), Catherine M. Biggs (Author), Kyla J. Hildebrand (Author), John Wu (Author), Sylvia Stockler-Ipsiroglu (Author), Stuart E. Turvey (Author)
• Format: Book
• Published: BMC, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background KRAS (KRAS proto-oncogene, GTPase; OMIM: 190,070) encodes one of three small guanosine triphosphatase proteins belonging to the RAS family. This group of proteins is responsible for cell proliferation, differentiation and inhibition of apoptosis. Gain-of-function variants in KRAS...