20(S)-Protopanaxadiol Inhibits Angiotensin II-Induced Epithelial- Mesenchymal Transition by Downregulating SIRT1

• Main Authors: Yuchen Wang (Author), Huali Xu (Author), Wenwen Fu (Author), Zeyuan Lu (Author), Minyu Guo (Author), Xueji Wu (Author), Mingyang Sun (Author), Yanzhe Liu (Author), Xiaofeng Yu (Author), Dayun Sui (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

20(S)-Protopanaxadiol (PPD) is one of the major active metabolites in ginseng saponin. Our previous studies revealed a broad spectrum of antitumor effects of PPD. Angiotensin II (Ang II), the biologically active peptide of the renin-angiotensin system (RAS), plays a critical role in the metastasis o...