Microcirculatory disturbance in acute liver injury is triggered by IFNγ-CD40 axis

• Main Authors: Miho Kurokawa (Author), Takeshi Goya (Author), Motoyuki Kohjima (Author), Masatake Tanaka (Author), Sadahiro Iwabuchi (Author), Shigeyuki Shichino (Author), Satoshi Ueha (Author), Tomonobu Hioki (Author), Tomomi Aoyagi (Author), Motoi Takahashi (Author), Koji Imoto (Author), Shigeki Tashiro (Author), Hideo Suzuki (Author), Masaki Kato (Author), Shinichi Hashimoto (Author), Hideo Matsuda (Author), Kouji Matsushima (Author), Yoshihiro Ogawa (Author)
• Format: Book
• Published: BMC, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Acute liver failure (ALF) is a life-threatening disorder that progresses from self-limiting acute liver injury (ALI). Microcirculatory disturbance characterized by sinusoidal hypercoagulation and subsequent massive hypoxic hepatocyte damage have been proposed to be the mechanism...