Identification of conserved and HLA promiscuous DENV3 T-cell epitopes.

• Main Authors: Eduardo J M Nascimento (Author), Robbie B Mailliard (Author), Asif M Khan (Author), John Sidney (Author), Alessandro Sette (Author), Nicole Guzman (Author), Michael Paulaitis (Author), Andréa Barbosa de Melo (Author), Marli T Cordeiro (Author), Laura V G Gil (Author), Françoir Lemonnier (Author), Charles Rinaldo (Author), J Thomas August (Author), Ernesto T A Marques (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Anti-dengue T-cell responses have been implicated in both protection and immunopathology. However, most of the T-cell studies for dengue include few epitopes, with limited knowledge of their inter-serotype variation and the breadth of their human leukocyte antigen (HLA) affinity. In order to expand...