Adaptive immunity against Leishmania nucleoside hydrolase maps its c-terminal domain as the target of the CD4+ T cell-driven protective response.

• Main Authors: Dirlei Nico (Author), Carla Claser (Author), Gulnara P Borja-Cabrera (Author), Luiz R Travassos (Author), Marcos Palatnik (Author), Irene da Silva Soares (Author), Mauricio Martins Rodrigues (Author), Clarisa B Palatnik- (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nucleoside hydrolases (NHs) show homology among parasite protozoa, fungi and bacteria. They are vital protagonists in the establishment of early infection and, therefore, are excellent candidates for the pathogen recognition by adaptive immune responses. Immune protection against NHs would prevent d...