Aldose Reductase Inhibitors Improve Myocardial Reperfusion Injury in Mice by a Dual Mechanism

• Main Authors: Kazumi Iwata (Author), Kuniharu Matsuno (Author), Toru Nishinaka (Author), Christina Persson (Author), Chihiro Yabe-Nishimura (Author)
• Format: Book
• Published: Elsevier, 2006-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aldose reductase (AR) has been implicated in the pathogenesis of diabetic complications, although the clinical efficacy of AR inhibitors has not been clearly proven. To clarify the pathophysiological role of AR in the heart, we investigated effects of AR inhibitors applied either during the pre-isch...