Evaluation of agonist and antagonist radioligands for somatostatin receptor imaging of breast cancer using positron emission tomography

• Main Authors: Iulia Dude (Author), Zhengxing Zhang (Author), Julie Rousseau (Author), Navjit Hundal-Jabal (Author), Nadine Colpo (Author), Helen Merkens (Author), Kuo-Shyan Lin (Author), François Bénard (Author)
• Format: Book
• Published: SpringerOpen, 2017-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The somatostatin receptor subtype 2 (sstr2) is expressed on a majority of luminal breast cancers, however SPECT and scintigraphy imaging with agonistic sstr2 probes has been sub-optimal. High affinity antagonists can access more binding sites on the cell surface, resulting in hig...