Ursolic acid induces apoptosis and autophagy of HCT-8/5-FU cells

• Main Authors: Jinyan ZHAO (Author), Shilan CHEN (Author), Xuejiao WANG (Author), Haixia SHANG (Author), Jiao PENG (Author), Jiumao LIN (Author)
• Format: Book
• Published: KeAi Communications Co., Ltd., 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

[Abstract]: Objective: To observe the effects of ursolic acid (UA) on the apoptosis, autophagy and mTOR of human colorectal cancer (CRC) cells resistant to 5-FU (HCT-8/5-FU), and explore the mechanisms of UA reversing the multidrug resistance (MDR) of CRC. Methods: HCT-8 cells and its resistant cell...