A phase 1, first-in-child, multicenter study to evaluate the safety and efficacy of the oncolytic herpes virus talimogene laherparepvec in pediatric patients with advanced solid tumors

• Main Authors: Lucas Moreno (Author), Pierre Teira (Author), James M. Croop (Author), Nicolas U. Gerber (Author), Nicolas André (Author), Isabelle Aerts (Author), Luis Gros Subias (Author), Bram De Wilde (Author), Francisco Bautista (Author), Brian Turpin (Author), Srinivasa Kunduri (Author), Ali Hamidi (Author), Tatiana Lawrence (Author), Keri A. Streby (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundThe survival rates for pediatric patients with relapsed and refractory tumors are poor. Successful treatment strategies are currently lacking and there remains an unmet need for novel therapies for these patients. We report here the results of a phase 1 study of talimogene laherparepvec (T...