THE DROPLET DIGITAL PCR: A NEW VALID MOLECULAR APPROACH FOR THE ASSESSMENT OF BRAFV600E MUTATION IN HAIRY CELL LEUKEMIA.

• Main Authors: Francesca Guerrini (Author), Matteo Paolicchi (Author), Francesco Ghio (Author), Elena Ciabatti (Author), Susanna Grassi (Author), Serena Salehzadeh (Author), Giacomo Ercolano (Author), Maria Rita Metelli (Author), Marzia Del Re (Author), Lorenzo Iovino (Author), Iacopo Petrini (Author), Giovanni Carulli (Author), Nadia Cecconi (Author), Martina Rousseau (Author), Giulia Cervetti (Author), Sara Galimberti (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hairy cell leukemia (HCL) is a chronic lymphoproliferative B-cell disorder where the B-RAF V600E mutation has been recently detected, as reported for solid neoplasias but not for other B-cell lymphomas. The digital droplet PCR (dd-PCR) is a molecular technique that, without standard references, is a...