Quantifying LAGA mutated mouse IgG2a monoclonal antibody with a rapid pepsin digestion enabled immunoaffinity LC/MS/MS assay

A sensitive and specific bioanalytical method was required to measure the exposure of a LAGA-mutated surrogate mouse IgG2a monoclonal antibody in mouse plasma, but the lack of highly specific reagents for the LAGA mutant hindered the development of a ligand-binding assay. Equally problematic is that...

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Main Authors: Linlin Dong (Author), Susan Chen (Author), Konstantin Piatkov (Author), Dong Wei (Author), Mark G. Qian (Author)
Format: Book
Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
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