Cytosolic Sensors of Viral RNA Are Involved in the Production of Interleukin-6 via Toll-Like Receptor 3 Signaling in Human Glomerular Endothelial Cells

• Main Authors: Qiang Liu (Author), Tadaatsu Imaizumi (Author), Tomomi Aizawa (Author), Koji Hirono (Author), Shogo Kawaguchi (Author), Shojiro Watanabe (Author), Koji Tsugawa (Author), Tomoh Matsumiya (Author), Kazuhiko Seya (Author), Hidemi Yoshida (Author), Hiroshi Tanaka (Author)
• Format: Book
• Published: Karger Publishers, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Aims: Dysregulation of interleukin-6 (IL-6) production in residual renal cells may play a pivotal role in the development of glomerulonephritis (GN). Given that Toll-like receptor 3 (TLR3) signaling has been implicated in the pathogenesis of some forms of GN, we examined activated TLR3-me...