T-cell engagers: model interrogation as a tool to quantify the interplay of relative affinity and target expression on trimer formation

• Main Authors: Massimo Lai (Author), Cesar Pichardo-Almarza (Author), Meghna Verma (Author), Md Shahinuzzaman (Author), Xu Zhu (Author), Holly Kimko (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

T-cell engagers (TCEs) represent a promising therapeutic strategy for various cancers and autoimmune disorders. These bispecific antibodies act as bridges, connecting T-cell receptors (TCRs) to target cells (either malignant or autoreactive) via interactions with specific tumour-associated antigens...