T-cell engagers: model interrogation as a tool to quantify the interplay of relative affinity and target expression on trimer formation

• मुख्य लेखकों: Massimo Lai (लेखक), Cesar Pichardo-Almarza (लेखक), Meghna Verma (लेखक), Md Shahinuzzaman (लेखक), Xu Zhu (लेखक), Holly Kimko (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

T-cell engagers (TCEs) represent a promising therapeutic strategy for various cancers and autoimmune disorders. These bispecific antibodies act as bridges, connecting T-cell receptors (TCRs) to target cells (either malignant or autoreactive) via interactions with specific tumour-associated antigens...