T-cell engagers: model interrogation as a tool to quantify the interplay of relative affinity and target expression on trimer formation

• Главные авторы: Massimo Lai (Автор), Cesar Pichardo-Almarza (Автор), Meghna Verma (Автор), Md Shahinuzzaman (Автор), Xu Zhu (Автор), Holly Kimko (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

T-cell engagers (TCEs) represent a promising therapeutic strategy for various cancers and autoimmune disorders. These bispecific antibodies act as bridges, connecting T-cell receptors (TCRs) to target cells (either malignant or autoreactive) via interactions with specific tumour-associated antigens...