Discovery of ecnoglutide - A novel, long-acting, cAMP-biased glucagon-like peptide-1 (GLP-1) analog

• Main Authors: Wanjun Guo (Author), Zheng Xu (Author), Haixia Zou (Author), Feng Li (Author), Yao Li (Author), Jing Feng (Author), Zhiyi Zhu (Author), Qing Zheng (Author), Rui Zhu (Author), Bin Wang (Author), Yan Li (Author), Sujuan Hao (Author), Hong Qin (Author), Catherine L. Jones (Author), Eric Adegbite (Author), Libnir Telusca (Author), Martijn Fenaux (Author), Weidong Zhong (Author), Mohammed K. Junaidi (Author), Susan Xu (Author), Hai Pan (Author)
• Format: Book
• Published: Elsevier, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Glucagon-like peptide (GLP)-1 is an incretin hormone that acts after food intake to stimulate insulin production, enhance satiety, and promote weight loss. Here we describe the discovery and characterization of ecnoglutide (XW003), a novel GLP-1 analog. Methods: We engineered a series of...