Optimizing Nanosuspension Drug Release and Wound Healing Using a Design of Experiments Approach: Improving the Drug Delivery Potential of NDH-4338 for Treating Chemical Burns

Optimizing Nanosuspension Drug Release and Wound Healing Using a Design of Experiments Approach: Improving the Drug Delivery Potential of NDH-4338 for Treating Chemical Burns

NDH-4338 is a highly lipophilic prodrug comprising indomethacin and an acetylcholinesterase inhibitor. A design of experiments approach was used to synthesize, characterize, and evaluate the wound healing efficacy of optimized NDH-4338 nanosuspensions against nitrogen mustard-induced skin injury. Na...

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Main Authors: Tomas L. Roldan (Author), Shike Li (Author), Christophe Guillon (Author), Ned D. Heindel (Author), Jeffrey D. Laskin (Author), In Heon Lee (Author), Dayuan Gao (Author), Patrick J. Sinko (Author)
Format: Book
Published: MDPI AG, 2024-03-01T00:00:00Z.
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