Development and validation of PAMPA-BBB QSAR model to predict brain penetration potential of novel drug candidates

• Main Authors: Rintaro Kato (Author), Wenyu Zeng (Author), Vishal B. Siramshetty (Author), Jordan Williams (Author), Md Kabir (Author), Natalie Hagen (Author), Elias C. Padilha (Author), Amy Q. Wang (Author), Ewy A. Mathé (Author), Xin Xu (Author), Pranav Shah (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Efficiently circumventing the blood-brain barrier (BBB) poses a major hurdle in the development of drugs that target the central nervous system. Although there are several methods to determine BBB permeability of small molecules, the Parallel Artificial Membrane Permeability Assay (PAMPA) is one of...