Sox11 regulates mammary tumour-initiating and metastatic capacity in Brca1-deficient mouse mammary tumour cells

• Main Authors: Siu Man Tsang (Author), Hyojin Kim (Author), Erik Oliemuller (Author), Richard Newman (Author), Naa-Anyima Boateng (Author), Naomi Guppy (Author), Beatrice A. Howard (Author)
• Format: Book
• Published: The Company of Biologists, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Little is known about the role of Sox11 in the regulation of mammary progenitor cells. Sox11 is expressed by mammary bud epithelial cells during embryonic mammary gland development and is not detected in mammary epithelial cells after birth. As Sox11 is an oncofetal gene, we investigated the effects...