Activation of Akt-mTORC1 signalling reverts cancer‐dependent muscle wasting

• Main Authors: Alessia Geremia (Author), Roberta Sartori (Author), Martina Baraldo (Author), Leonardo Nogara (Author), Valeria Balmaceda (Author), Georgia Ana Dumitras (Author), Stefano Ciciliot (Author), Marco Scalabrin (Author), Hendrik Nolte (Author), Bert Blaauw (Author)
• Format: Book
• Published: Wiley, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Cancer‐related muscle wasting occurs in most cancer patients. An important regulator of adult muscle mass and function is the Akt-mTORC1 pathway. While Akt-mTORC1 signalling is important for adult muscle homeostasis, it is also a major target of numerous cancer treatments. Which...