A quantitative systems pharmacology modeling platform for evaluating triglyceride profiles in patients with high triglycerides receiving evinacumab

• Main Authors: Masood Khaksar Toroghi (Author), Jim Bosley (Author), Lyn M. Powell (Author), Yi Zhang (Author), Feng Yang (Author), Xia Pu (Author), John D. Davis (Author), Nidal Al‐Huniti (Author)
• Format: Book
• Published: Wiley, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract A model to quantitatively characterize the effect of evinacumab, an investigational monoclonal antibody against angiopoietin‐like protein 3 (ANGPTL3) on lipid trafficking is needed. A quantitative systems pharmacology (QSP) approach was developed to predict the transient responses of differ...