Antiepileptic Drugs Elevate Astrocytic Kir4.1 Expression in the Rat Limbic Region

• Main Authors: Takahiro Mukai (Author), Masato Kinboshi (Author), Yuki Nagao (Author), Saki Shimizu (Author), Asuka Ono (Author), Yoshihisa Sakagami (Author), Aoi Okuda (Author), Megumi Fujimoto (Author), Hidefumi Ito (Author), Akio Ikeda (Author), Yukihiro Ohno (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inwardly rectifying potassium (Kir) channel subunits Kir4.1 are specifically expressed in astrocytes and regulate neuronal excitability by mediating spatial potassium buffering. In addition, it is now known that astrocytic Kir4.1 channels are closely involved in the pathogenesis of epilepsy. Here, t...