Anti-cancer strategy targeting the energy metabolism of tumor cells surviving a low-nutrient acidic microenvironment

• Main Authors: Yuki Maeda (Author), Ryota Kikuchi (Author), Junichiro Kawagoe (Author), Takao Tsuji (Author), Nobuyuki Koyama (Author), Kazuhiro Yamaguchi (Author), Hiroyuki Nakamura (Author), Kazutetsu Aoshiba (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Tumor cells experience hypoxia, acidosis, and hypoglycemia. Metabolic adaptation to glucose shortage is essential to maintain tumor cells' survival because of their high glucose requirement. This study evaluated the hypothesis that acidosis might promote tumor survival during glucose...