"Endothelial Antibody Factory" at the Blood Brain Barrier: Novel Approach to Therapy of Neurodegenerative Diseases

• Main Authors: Reynald Thinard (Author), Attila E. Farkas (Author), Marta Halasa (Author), Melanie Chevalier (Author), Klaudia Brodaczewska (Author), Aleksandra Majewska (Author), Robert Zdanowski (Author), Maria Paprocka (Author), Joanna Rossowska (Author), Lam Tri Duc (Author), Ruth Greferath (Author), Istvan Krizbai (Author), Fred Van Leuven (Author), Claudine Kieda (Author), Claude Nicolau (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The failures of anti-β-amyloid immunotherapies suggested that the very low fraction of injected antibodies reaching the brain parenchyma due to the filtering effect of the BBB may be a reason for the lack of therapeutic effect. However, there is no treatment, as yet, for the amyotrophic lateral scle...