JAK inhibition ameliorated experimental autoimmune encephalomyelitis by blocking GM-CSF-driven inflammatory signature of monocytes

• Auteurs principaux: Shuai Shao (Auteur), Chengjuan Chen (Auteur), Gaona Shi (Auteur), Yu Zhou (Auteur), Yazi Wei (Auteur), Lei Wu (Auteur), Lan Sun (Auteur), Tiantai Zhang (Auteur)
• Format: Livre
• Publié: Elsevier, 2023-10-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Monocytes are key effectors in autoimmunity-related diseases in the central nervous system (CNS) due to the critical roles of these cells in the production of proinflammatory cytokines, differentiation of T-helper (Th) cells, and antigen presentation. The JAK-STAT signaling is crucial for initiating...