CYP2D6 gene polymorphism and apatinib affect the metabolic profile of fluvoxamine

• Main Authors: Zhize Ye (Author), Bingbing Chen (Author), Nanyong Gao (Author), Qihui Kong (Author), Xiaoqin Hu (Author), Zhongqiu Lu (Author), Jianchang Qian (Author), Guoxin Hu (Author), Jianping Cai (Author), Bin Wu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study aimed 1) to investigate the influence of CYP2D6 variants on the catalyzing of fluvoxamine, and 2) to study the interaction between fluvoxamine and apatinib. An enzymatic reaction system was setup and the kinetic profile of CYP2D6 in metabolizing fluvoxamine was determined. In vivo, drug-d...