Assessment and prediction of tablet properties using transmission and backscattering Raman spectroscopy and transmission NIR spectroscopy

• Κύριοι συγγραφείς: Elisabeth Peeters (Συγγραφέας), Ana Filipa Tavares da Silva (Συγγραφέας), Maunu Toiviainen (Συγγραφέας), Jeroen Van Renterghem (Συγγραφέας), Jurgen Vercruysse (Συγγραφέας), Mikko Juuti (Συγγραφέας), Joao Almeida Lopes (Συγγραφέας), Thomas De Beer (Συγγραφέας), Chris Vervaet (Συγγραφέας), Jean-Paul Remon (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Elsevier, 2016-08-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Περίληψη

This study investigated whether Raman and Near Infrared (NIR) spectroscopy could predict tablet properties. Granules were produced on a continuous line by varying granulation parameters. Tableting process parameters were adjusted to obtain uniform tablet weight and thickness. Spectra were collected offline and tablet properties determined with traditional analyzing methods. Partial Least Squares (PLS) regression was used to correlate spectral information to tablet properties, but predictive models couldn't be established. Principal component analysis (PCA) was effectively used to distinguish theophylline concentrations and hydration levels and multiple linear regression (MLR) analysis allowed insight on how granulation parameters affect granule and tablet properties.

Περιγραφή τεκμηρίου

1818-0876
10.1016/j.ajps.2016.04.004