The malnutrition-related increase in early visceralization of Leishmania donovani is associated with a reduced number of lymph node phagocytes and altered conduit system flow.

• Main Authors: Marwa K Ibrahim (Author), Jeffrey L Barnes (Author), Gregory M Anstead (Author), Fabio Jimenez (Author), Bruno L Travi (Author), Alex G Peniche (Author), E Yaneth Osorio (Author), Seema S Ahuja (Author), Peter C Melby (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In a murine model of moderate childhood malnutrition we found that polynutrient deficiency led to a 4-5-fold increase in early visceralization of L. donovani (3 days post-infection) following cutaneous infection and a 16-fold decrease in lymph node barrier function (p<0.04 for all). To begin to u...