The malnutrition-related increase in early visceralization of Leishmania donovani is associated with a reduced number of lymph node phagocytes and altered conduit system flow.

• Главные авторы: Marwa K Ibrahim (Автор), Jeffrey L Barnes (Автор), Gregory M Anstead (Автор), Fabio Jimenez (Автор), Bruno L Travi (Автор), Alex G Peniche (Автор), E Yaneth Osorio (Автор), Seema S Ahuja (Автор), Peter C Melby (Автор)
• Формат: ‌
• Опубликовано: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Предметы: article
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In a murine model of moderate childhood malnutrition we found that polynutrient deficiency led to a 4-5-fold increase in early visceralization of L. donovani (3 days post-infection) following cutaneous infection and a 16-fold decrease in lymph node barrier function (p<0.04 for all). To begin to u...