Hyperreactive onchocerciasis is characterized by a combination of Th17-Th2 immune responses and reduced regulatory T cells.

• Main Authors: Gnatoulma Katawa (Author), Laura E Layland (Author), Alex Y Debrah (Author), Charlotte von Horn (Author), Linda Batsa (Author), Alexander Kwarteng (Author), Sandra Arriens (Author), David W Taylor (Author), Sabine Specht (Author), Achim Hoerauf (Author), Tomabu Adjobimey (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Clinical manifestations in onchocerciasis range from generalized onchocerciasis (GEO) to the rare but severe hyperreactive (HO)/sowda form. Since disease pathogenesis is associated with host inflammatory reactions, we investigated whether Th17 responses could be related to aggravated pathology in HO...