The uricosuric effects of dihydropyridine calcium channel blockers in vivo using urate under-excretion animal models

• Main Authors: Takayuki Hori (Author), Motoshi Ouchi (Author), Naoyuki Otani (Author), Masakatsu Nohara (Author), Asuka Morita (Author), Yusuke Otsuka (Author), Promsuk Jutabha (Author), Ikuko Shibasaki (Author), Yasushi Matsushita (Author), Tomoe Fujita (Author), Hirotsugu Fukuda (Author), Naohiko Anzai (Author)
• Format: Book
• Published: Elsevier, 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The purpose of this study was to create novel urate under-excretion animal models using pyrazinamide and to evaluate whether dihydropyridine calcium channel blockers (CCBs) have uricosuric effects in vivo.Adult male ICR mice were treated with pyrazinamide, vehicle (dimethyl sulfoxide: DMSO), or tap...