Gene expression profiling of fibroblasts in a family with LMNA-related cardiomyopathy reveals molecular pathways implicated in disease pathogenesis

• Główni autorzy: Halida P. Widyastuti (Autor), Trina M. Norden-Krichmar (Autor), Anna Grosberg (Autor), Michael V. Zaragoza (Autor)
• Format: Książka
• Wydane: BMC, 2020-07-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Abstract Background Intermediate filament proteins that construct the nuclear lamina of a cell include the Lamin A/C proteins encoded by the LMNA gene, and are implicated in fundamental processes such as nuclear structure, gene expression, and signal transduction. LMNA mutations predominantly affect...