Janus kinase inhibitors for the treatment of rheumatoid arthritis demonstrate similar profiles of in vitro cytokine receptor inhibition

• Main Authors: Martin E. Dowty (Author), Tsung H. Lin (Author), Michael I. Jesson (Author), Martin Hegen (Author), David A. Martin (Author), Vaibhav Katkade (Author), Sujatha Menon (Author), Jean‐Baptiste Telliez (Author)
• Format: Book
• Published: Wiley, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Janus kinase (JAK) inhibitors have emerged as an effective class of therapies for various inflammatory diseases such as rheumatoid arthritis (RA). JAK inhibitors function intracellularly by modulating the catalytic activity of JAKs and disrupting the receptor‐mediated signaling of multiple...