Synergistic Stimulation with Different TLR7 Ligands Modulates Gene Expression Patterns in the Human Plasmacytoid Dendritic Cell Line CAL-1

Synergistic Stimulation with Different TLR7 Ligands Modulates Gene Expression Patterns in the Human Plasmacytoid Dendritic Cell Line CAL-1

Objective. TLR7 ligation in plasmacytoid dendritic cells is promising for the treatment of cancer, allergy, and infectious diseases; however, high doses of ligands are required. We hypothesized that the combination of structurally different TLR7 ligands exponentiates the resulting immune response. M...

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Main Authors: Tobias Hilbert (Author), Folkert Steinhagen (Author), Christina Weisheit (Author), Georg Baumgarten (Author), Andreas Hoeft (Author), Sven Klaschik (Author)
Format: Book
Published: Hindawi Limited, 2015-01-01T00:00:00Z.
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