Synergistic Stimulation with Different TLR7 Ligands Modulates Gene Expression Patterns in the Human Plasmacytoid Dendritic Cell Line CAL-1

• Váldodahkkit: Tobias Hilbert (Dahkki), Folkert Steinhagen (Dahkki), Christina Weisheit (Dahkki), Georg Baumgarten (Dahkki), Andreas Hoeft (Dahkki), Sven Klaschik (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Hindawi Limited, 2015-01-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Objective. TLR7 ligation in plasmacytoid dendritic cells is promising for the treatment of cancer, allergy, and infectious diseases; however, high doses of ligands are required. We hypothesized that the combination of structurally different TLR7 ligands exponentiates the resulting immune response. M...