Pharmacological Characterization of T-2328, 2-Fluoro-4'-methoxy- 3'-[[[(2S,3S )-2-phenyl-3-piperidinyl]amino]methyl]-[1,1'-biphenyl]-4- carbonitrile Dihydrochloride, as a Brain-Penetrating Antagonist of Tachykinin NK1Receptor

• Главные авторы: Yumi Watanabe (Автор), Hidetoshi Asai (Автор), Taketoshi Ishii (Автор), Satoko Kiuchi (Автор), Masahito Okamoto (Автор), Hiroyuki Taniguchi (Автор), Masaaki Nagasaki (Автор), Akira Saito (Автор)
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• Опубликовано: Elsevier, 2008-01-01T00:00:00Z.
• Предметы: article
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The pharmacological properties of T-2328 were evaluated as an antagonist of the tachykinin neurokinin 1 (NK1) receptor. T-2328 inhibited the specific binding of [3H][Sar9,Met(O2)11]substance P to tachykinin NK1receptors in human lymphoblastic IM9 cells with Kiof 0.08 nM. In the same assay, Kifor apr...