Pharmacological Characterization of T-2328, 2-Fluoro-4'-methoxy- 3'-[[[(2S,3S )-2-phenyl-3-piperidinyl]amino]methyl]-[1,1'-biphenyl]-4- carbonitrile Dihydrochloride, as a Brain-Penetrating Antagonist of Tachykinin NK1Receptor

• Main Authors: Yumi Watanabe (Author), Hidetoshi Asai (Author), Taketoshi Ishii (Author), Satoko Kiuchi (Author), Masahito Okamoto (Author), Hiroyuki Taniguchi (Author), Masaaki Nagasaki (Author), Akira Saito (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The pharmacological properties of T-2328 were evaluated as an antagonist of the tachykinin neurokinin 1 (NK1) receptor. T-2328 inhibited the specific binding of [3H][Sar9,Met(O2)11]substance P to tachykinin NK1receptors in human lymphoblastic IM9 cells with Kiof 0.08 nM. In the same assay, Kifor apr...