Geranylgeranylacetone Ameliorates Skin Inflammation by Regulating and Inducing Thioredoxin via the Thioredoxin Redox System

• Main Authors: Tiancheng Jin (Author), Yitong You (Author), Wenjie Fan (Author), Junyang Wang (Author), Yuhao Chen (Author), Shujing Li (Author), Siyuan Hong (Author), Yaxuan Wang (Author), Ruijie Cao (Author), Junji Yodoi (Author), Hai Tian (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Geranylgeranylacetone (GGA) exerts cytoprotective activity against various toxic stressors via the thioredoxin (TRX) redox system; however, its effect on skin inflammation and molecular mechanism on inducing the TRX of GGA is still unknown. We investigated the effects of GGA in a murine irritant con...