Impact of CYP2C19, CYP3A4, ABCB1, and FMO3 genotypes on plasma voriconazole in Thai patients with invasive fungal infections

• Главные авторы: Sumonrat Chuwongwattana (Автор), Thawinee Jantararoungtong (Автор), Santirat Prommas (Автор), Sadeep Medhasi (Автор), Apichaya Puangpetch (Автор), Chonlaphat Sukasem (Автор)
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• Опубликовано: Wiley, 2020-12-01T00:00:00Z.
• Предметы: article
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Abstract Voriconazole is the first‐line antifungal choice in the treatment of invasive fungal infections (IFIs). Single nucleotide polymorphisms (SNPs) in drug‐metabolizing and transporter genes may affect voriconazole pharmacokinetics. This study aimed to determine the frequency of the CYP2C19 rs42...