The generation of PD-L1 and PD-L2 in cancer cells: From nuclear chromatin reorganization to extracellular presentation

• Main Authors: Zhiwei Fan (Author), Changyue Wu (Author), Miaomiao Chen (Author), Yongying Jiang (Author), Yuanyuan Wu (Author), Renfang Mao (Author), Yihui Fan (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The immune checkpoint blockade (ICB) targeting on PD-1/PD-L1 has shown remarkable promise in treating cancers. However, the low response rate and frequently observed severe side effects limit its broad benefits. It is partially due to less understanding of the biological regulation of PD-L1. Here, w...